The ability of MRI in providing multiplanar 3D images with high resolution, which accurately discern soft tissues and demonstrate visually inaccessible organs, made it an exclusive imaging technique. In this regard, MRI can be used in the treatment of chronic diseases and longitudinal studies. This is the advantage of MRI compared to other imaging modalities such as computed tomography methods. In this exceptional non-invasive imaging technique, powerful magnetic fields and radio-waves are used to obtain quantitative anatomical, physiological and metabolic information of human body without applying any ionizing radiation. Magnetic resonance imaging (MRI) has a wide spectrum of clinical applications as an advanced imaging approach including diagnosis, staging and management of diseases because of its physical properties. We briefly reviewed the different types of contrast agents and focused on the studies in which natural oral contrast agents used to investigate their efficacy in increasing the gastrointestinal magnetic resonance imaging clarity. Some advantages have been reported regarding the natural types of contrast agents over the artificial agents including better taste and tolerability. Natural contrast agents consist of fruit juice or pulps. Oral contrast agents can be the artificial materials or natural factors. Various types of contrast agents have been used in studies including intravascular administration and oral materials. Magnetic resonance imaging is a non-invasive method, but contrast agents are necessary to enhance the visualization of inaccessible organs in some organs such as gastrointestinal (GI) imaging. Magnetic resonance imaging is able to provide quantitative data regarding the anatomical and physiological features of each specific organ. Magnetic resonance imaging is an exclusive imaging method which can distinguish injured tissues from the healthy tissues or organs without using ionizing radiation.
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